Schizophrenia

Remission was defined as SAPS and SANS scores of less than 2 for more than 6 months and clinical recovery as no psychotic episode, psychiatric hospitalizations, ...

Similarly, the EIS recipients had lower negative symptom scores than TAU recipients at 1 (MD, -0.35; P =.001) and 2 (MD, -0.45; P =.001) years but not at the longer follow-ups. [Clinical recovery and long-term association of specialized early intervention services vs treatment as usual among individuals with first-episode schizophrenia spectrum disorder 20-year follow-up of the OPUStTrial](https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2801903). The EIS recipients had significantly lower psychotic symptom dimension scores at the 1- (mean difference [MD], -0.30; P =.02) and 2- (MD, -0.34; P =.01) year follow-ups but no differences were observed at 5 (P =.58), 10 (P =.99), or 20 (P =.48) years compared with TAU. The follow-up cohort comprised patients with a mean age of 45.93 (SD, 5.47) years, 51.8% were women, 93.9% lived independently, 43.3% were a parent, 15.9% had completed 5 to 6 years of education after high school, and 14.9% had substance or alcohol use disorder. Remission was defined as SAPS and SANS scores of less than 2 for more than 6 months and clinical recovery as no psychotic episode, psychiatric hospitalizations, and supported accommodation for 2 consecutive years. Patients (N=547) with schizophrenia spectrum disorders were recruited in Aarhus and Copenhagen in Denmark between 1998 and 2000 for the Danish OPUS trial. The patients received either EIS or TAU for 2 years. Excluding patients who had schizotypal disorders at baseline, the remission rates were 37.5% of 42 patients in the EIS group and 42% of 37 patients in the TAU group and the rates of clinical recovery were 14.1% and 21.2%, respectively. doi:10.1001/jamapsychiatry.2022.5164 Significant time-by-intervention interactions were observed for the negative symptom dimension (F[4,267.896], 5.037; P ≤.001) and for GAF-F scores (F[4,303.476], 2.501; P =.04) but not for psychotic symptom dimension (F[4,283.695], 2.195; P =.07). In this study the changes in Scale for Assessment for Positive Symptoms (SAPS), Scale for Assessment of Negative Symptoms (SANS), and Global Assessment of Functioning scale (GAF-F) outcomes over 20 years were evaluated. Overall, data from 164 patients were available at 20 years.